COX6A2

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]

Description

Cytochrome c oxidase subunit 6A2

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (31427731 - 31428360)

Ensembl ID

ENSG00000156885  (ver. 103.38)

Orthologs

Mouse Cox6a2: ENSMUSG00000030785

UniProt

Q02221

neXtProt

NX_Q02221

Human splice variants
Mouse splice variants

Protein structure