ADAMTS14

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 14

Tissue specificity

Tissue enhanced (brain, gallbladder, placenta)

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

10 (70672506 - 70762441)

Ensembl ID

ENSG00000138316  (ver. 103.38)

Orthologs

Mouse Adamts14: ENSMUSG00000059901

UniProt

Q8WXS8

neXtProt

NX_Q8WXS8

Human splice variants
Mouse splice variants

Protein structure