PLXNC1

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Description

Plexin C1

Tissue specificity

Low tissue specificity

Subcell location

Mitochondria

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (94148577 - 94307675)

Ensembl ID

ENSG00000136040  (ver. 103.38)

Orthologs

Mouse Plxnc1: ENSMUSG00000074785

UniProt

O60486

neXtProt

NX_O60486

Human splice variants
Mouse splice variants

Protein structure