PON2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Paraoxonase 2

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular, Secreted to blood

Protein family

Candidate cardiovascular disease genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (95404862 - 95435329)

Ensembl ID

ENSG00000105854  (ver. 103.38)

Orthologs

Mouse Pon2: ENSMUSG00000032667

UniProt

Q15165

neXtProt

NX_Q15165

Human splice variants
Mouse splice variants

Protein structure