VDAC1

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. [provided by RefSeq, Sep 2010]

Description

Voltage dependent anion channel 1

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (133971871 - 134004975)

Ensembl ID

ENSG00000213585  (ver. 103.38)

Orthologs

Mouse Vdac1: ENSMUSG00000020402

UniProt

P21796

neXtProt

NX_P21796

Human splice variants
Mouse splice variants

Protein structure