MMP20

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Description

Matrix metallopeptidase 20

Tissue specificity

Not detected

Predicted location

Secreted to extracellular matrix

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted secreted proteins

Chromosome

11 (102576832 - 102625332)

Ensembl ID

ENSG00000137674  (ver. 103.38)

Orthologs

Mouse Mmp20: ENSMUSG00000018620

UniProt

O60882

neXtProt

NX_O60882

Human splice variants
Mouse splice variants

Protein structure