MMP17

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

Description

Matrix metallopeptidase 17

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

12 (131828393 - 131851783)

Ensembl ID

ENSG00000198598  (ver. 103.38)

Orthologs

Mouse Mmp17: ENSMUSG00000029436

UniProt

Q9ULZ9

neXtProt

NX_Q9ULZ9

Human splice variants
Mouse splice variants

Protein structure