Tissue expression
Cell line expression
Protein structure
PRKAB2
Protein kinase AMP-activated non-catalytic subunit beta 2The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Top validated antibodies |
|||||
Invitrogen Antibodies | MA5-31864 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
LSBio | LS-C748394 | Polyclonal |
WB
ICC
IHC
|
||
antibodies-online | ABIN359114 | 5 references | Polyclonal |
WB
IHC |
|
Proteintech Group | 14429-1-AP | Polyclonal |
WB
EL
ICC
IHC |
||
Boster Biological Technology | M05077 | Monoclonal |
WB
ICC
IHC
FC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider