Tissue expression
Cell line expression
Protein structure
EIF4G1
Eukaryotic translation initiation factor 4 gamma 1EIF4F, EIF4G, p220, PARK18
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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Proteintech Group | ![]() |
11 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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antibodies-online | ![]() |
5 references | Polyclonal |
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Boster Biological Technology | ![]() |
Polyclonal |
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Atlas Antibodies | ![]() |
Polyclonal |
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