GPBAR1

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Description

G protein-coupled bile acid receptor 1

Tissue specificity

Tissue enhanced (adipose tissue, breast, gallbladder)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

2 (218259496 - 218263861)

Ensembl ID

ENSG00000179921  (ver. 103.38)

Orthologs

Mouse Gpbar1: ENSMUSG00000064272

UniProt

Q8TDU6

neXtProt

NX_Q8TDU6

Human splice variants
Mouse splice variants

Protein structure