Tissue expression
Cell line expression
Protein structure
GPBAR1
G protein-coupled bile acid receptor 1BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
1 references | Polyclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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Cusabio Biotech Co., Ltd | ![]() |
Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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NSJ Bioreagents | ![]() |
Polyclonal |
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