DYRK3

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

Dual specificity tyrosine phosphorylation regulated kinase 3

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (206635536 - 206684419)

Ensembl ID

ENSG00000143479  (ver. 103.38)

Orthologs

Mouse Dyrk3: ENSMUSG00000016526

UniProt

O43781

neXtProt

NX_O43781

Human splice variants
Mouse splice variants

Protein structure