CCR7

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Description

C-C motif chemokine receptor 7

Tissue specificity

Tissue enhanced (intestine, lymphoid tissue)

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (40553769 - 40565472)

Ensembl ID

ENSG00000126353  (ver. 103.38)

Orthologs

Mouse Ccr7: ENSMUSG00000037944

UniProt

P32248

neXtProt

NX_P32248

Human splice variants
Mouse splice variants

Protein structure