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ACLY
ATP citrate lyaseACL, ATPCL, CLATP
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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| Proteintech Group |  15421-1-AP |
65 references | Polyclonal |
WB
EL
ICC
IP
FC
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| antibodies-online | ABIN1098143 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Invitrogen Antibodies | 15421-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| GeneTex | GTX60666 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| Novus Biologicals | NBP2-37429 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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