SELL

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Description

Selectin L

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Cytosol

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (169690665 - 169711702)

Ensembl ID

ENSG00000188404  (ver. 103.38)

Orthologs

Mouse Sell: ENSMUSG00000026581

UniProt

P14151

neXtProt

NX_P14151

Human splice variants
Mouse splice variants

Protein structure