SELPLG

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Description

Selectin P ligand

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Candidate cardiovascular disease genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (108621895 - 108633894)

Ensembl ID

ENSG00000110876  (ver. 103.38)

Orthologs

Mouse Selplg: ENSMUSG00000048163

UniProt

Q14242

neXtProt

NX_Q14242

Human splice variants
Mouse splice variants

Protein structure