CD48

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Description

CD48 molecule

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Nucleoli fibrillar center, Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (160678746 - 160711831)

Ensembl ID

ENSG00000117091  (ver. 103.38)

Orthologs

Mouse Cd48: ENSMUSG00000015355

UniProt

P09326

neXtProt

NX_P09326

Human splice variants
Mouse splice variants

Protein structure