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PLCG2
Phospholipase C gamma 2The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-120010 |
Polyclonal |
WB
ICC
IHC
FC
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| antibodies-online | ABIN4880951 |
Monoclonal |
WB
EL
ICC
FC
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| Novus Biologicals | NBP2-52534 |
Monoclonal |
WB
EL
ICC
FC
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| Biorbyt | orb15006 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A03572-1 |
1 references | Polyclonal |
WB
EL
IHC
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