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Protein structure
VDR
Vitamin D receptorNR1I1, PPP1R163
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
Top validated antibodies |
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| Invitrogen Antibodies |  MA1-710 |
114 references | Monoclonal |
WB
ICC
IP
GS
ChIP
OA
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| LSBio | LS-C352989 |
Polyclonal |
WB
ICC
IHC
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| R&D Systems | PP-H4537-00 |
2 references | Monoclonal |
WB
EL
IP
IHC
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| Novus Biologicals | PP-H4537-00 |
2 references | Monoclonal |
WB
EL
IP
IHC
|
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| Bioss | bs-2987R |
3 references | Polyclonal |
WB
ICC
IHC
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|
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