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PTPN11
Protein tyrosine phosphatase non-receptor type 11BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| Proteintech Group |  20145-1-AP |
30 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN1098117 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NB100-806 |
1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX60640 |
Monoclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C801630 |
Polyclonal |
WB
EL
ICC
IHC
|
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