SOAT1

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Description

Sterol O-acyltransferase 1

Tissue specificity

Tissue enriched (adrenal gland)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (179293714 - 179358680)

Ensembl ID

ENSG00000057252  (ver. 103.38)

Orthologs

Mouse Soat1: ENSMUSG00000026600

UniProt

P35610

neXtProt

NX_P35610

Human splice variants
Mouse splice variants

Protein structure