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IDH3G
Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| NSJ Bioreagents |  RQ8518 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C404585 |
Polyclonal |
WB
EL
IHC
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| Novus Biologicals | NBP1-85810 |
2 references | Polyclonal |
WB
ICC
IHC
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| Proteintech Group | 25848-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| Atlas Antibodies | HPA002017 |
4 references | Polyclonal |
WB
ICC
IHC
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