PSMD10

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. [provided by RefSeq, Mar 2011]

Description

Proteasome 26S subunit, non-ATPase 10

Tissue specificity

Low tissue specificity

Subcell location

Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (108084207 - 108091549)

Ensembl ID

ENSG00000101843  (ver. 103.38)

Orthologs

Mouse Psmd10: ENSMUSG00000031429

UniProt

O75832

neXtProt

NX_O75832

Human splice variants
Mouse splice variants

Protein structure