BANK1

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

B cell scaffold protein with ankyrin repeats 1

Tissue specificity

Group enriched (intestine, lymphoid tissue)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

4 (101411286 - 102074812)

Ensembl ID

ENSG00000153064  (ver. 103.38)

Orthologs

Mouse Bank1: ENSMUSG00000037922

UniProt

Q8NDB2

neXtProt

NX_Q8NDB2

Human splice variants
Mouse splice variants

Protein structure