KCNB2

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily B member 2

Tissue specificity

Tissue enhanced (brain, lymphoid tissue, retina)

Subcell location

Nucleoli, Plasma membrane, Midbody

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

8 (72537225 - 72938349)

Ensembl ID

ENSG00000182674  (ver. 103.38)

Orthologs

-

UniProt

Q92953

neXtProt

NX_Q92953

Human splice variants

Protein structure