DEFB114

Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014]

Description

Defensin beta 114

Tissue specificity

Tissue enriched (epididymis)

Predicted location

Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

6 (49960249 - 49964164)

Ensembl ID

ENSG00000177684  (ver. 103.38)

Orthologs

-

UniProt

Q30KQ6

neXtProt

NX_Q30KQ6

Human splice variants

Protein structure