CTNNBL1

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Description

Catenin beta like 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (37693955 - 37872129)

Ensembl ID

ENSG00000132792  (ver. 103.38)

Orthologs

Mouse Ctnnbl1: ENSMUSG00000027649

UniProt

Q8WYA6

neXtProt

NX_Q8WYA6

Human splice variants
Mouse splice variants

Protein structure