RGS5

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

Description

Regulator of G protein signaling 5

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

1 (163111121 - 163321791)

Ensembl ID

ENSG00000143248  (ver. 103.38)

Orthologs

Mouse Rgs5: ENSMUSG00000026678

UniProt

O15539

neXtProt

NX_O15539

Human splice variants
Mouse splice variants

Protein structure