CD38

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Description

CD38 molecule

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Cancer-related genes
CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (15778275 - 15853232)

Ensembl ID

ENSG00000004468  (ver. 103.38)

Orthologs

Mouse Cd38: ENSMUSG00000029084

UniProt

P28907

neXtProt

NX_P28907

Human splice variants
Mouse splice variants

Protein structure