TRPM2

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

Description

transient receptor potential cation channel subfamily M member 2

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas), Transporters

Chromosome

21:q22.3 (44350163 - 44443081)

Ensembl ID

ENSG00000142185  (ver. 99.38)

Orthologs

Mouse Trpm2: ENSMUSG00000009292

UniProt

O94759

neXtProt

NX_O94759

Human splice variants
Mouse splice variants