TLR10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Description

Toll like receptor 10

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Centrosome, Cytosol

Predicted location

Intracellular, Membrane

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (38772238 - 38782990)

Ensembl ID

ENSG00000174123  (ver. 103.38)

Orthologs

-

UniProt

Q9BXR5

neXtProt

NX_Q9BXR5

Human splice variants

Protein structure