MAPRE1

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Description

Microtubule associated protein RP/EB family member 1

Tissue specificity

Low tissue specificity

Subcell location

Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (32819954 - 32850405)

Ensembl ID

ENSG00000101367  (ver. 103.38)

Orthologs

Mouse Mapre1: ENSMUSG00000027479

UniProt

Q15691

neXtProt

NX_Q15691

Human splice variants
Mouse splice variants

Protein structure