CSRNP1

This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Description

Cysteine and serine rich nuclear protein 1

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

3 (39141855 - 39154562)

Ensembl ID

ENSG00000144655  (ver. 103.38)

Orthologs

Mouse Csrnp1: ENSMUSG00000032515

UniProt

Q96S65

neXtProt

NX_Q96S65

Human splice variants
Mouse splice variants

Protein structure