CCR8

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Description

C-C motif chemokine receptor 8

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

CD markers
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

3 (39329709 - 39333680)

Ensembl ID

ENSG00000179934  (ver. 103.38)

Orthologs

Mouse Ccr8: ENSMUSG00000042262

UniProt

P51685

neXtProt

NX_P51685

Human splice variants
Mouse splice variants

Protein structure