ITGB1BP2

This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]

Description

Integrin subunit beta 1 binding protein 2

Tissue specificity

Tissue enhanced (heart muscle, skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (71301750 - 71305371)

Ensembl ID

ENSG00000147166  (ver. 103.38)

Orthologs

Mouse Itgb1bp2: ENSMUSG00000031312

UniProt

Q9UKP3

neXtProt

NX_Q9UKP3

Human splice variants
Mouse splice variants

Protein structure