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Protein structure
KCNQ2
Potassium voltage-gated channel subfamily Q member 2BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, Kv7.2
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN2482764 |
3 references | Monoclonal |
WB
ICC
IP
IHC
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| LSBio | LS-B7458 |
Monoclonal |
WB
ICC
IP
IHC
BN
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| Novus Biologicals | NBP2-12898 |
Monoclonal |
WB
ICC
IP
IHC
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| Invitrogen Antibodies | PA1-929 |
6 references | Polyclonal |
ICC
OA
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| Abnova Corporation | MAB6655 |
2 references | Monoclonal |
WB
ICC
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