HOXC11

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Description

Homeobox C11

Tissue specificity

Tissue enhanced (skeletal muscle, skin)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Chromosome

12 (53973126 - 53977643)

Ensembl ID

ENSG00000123388  (ver. 103.38)

Orthologs

Mouse Hoxc11: ENSMUSG00000001656

UniProt

O43248

neXtProt

NX_O43248

Human splice variants
Mouse splice variants

Protein structure