Tissue expression
Cell line expression
Protein structure
IDH2
Isocitrate dehydrogenase (NADP(+)) 2Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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Atlas Antibodies | HPA007831 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Proteintech Group | 15932-1-AP | 21 references | Polyclonal |
WB
EL
IP
IHC |
|
Invitrogen Antibodies | PA5-96605 | Polyclonal |
WB
ICC
IP
IHC
ChIP
OA |
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Novus Biologicals | H00003418-M01 | 4 references | Monoclonal |
WB
EL
IHC
|
|
antibodies-online | ABIN2970585 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
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