PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Description

Progastricsin

Tissue specificity

Tissue enriched (stomach)

Subcell location

Nucleoplasm

Predicted location

Intracellular, Secreted to digestive system

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

6 (41736711 - 41754109)

Ensembl ID

ENSG00000096088  (ver. 103.38)

Orthologs

Mouse Pgc: ENSMUSG00000023987

UniProt

P20142

neXtProt

NX_P20142

Human splice variants
Mouse splice variants

Protein structure