APLP1

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Amyloid beta precursor like protein 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Golgi apparatus, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (35867899 - 35879792)

Ensembl ID

ENSG00000105290  (ver. 103.38)

Orthologs

Mouse Aplp1: ENSMUSG00000006651

UniProt

P51693

neXtProt

NX_P51693

Human splice variants
Mouse splice variants

Protein structure