Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 14-9015-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Immunogen sequence: MEGVLYKWT NYLTGWQPRW FVLDNGILSY YDSQDDVCKG SKGSIKMAVC EIKVHSADNT RMELIIPGEQ HFYMKAVNAA ERQRWLVALG SSKACLTDTR TKKEKEISET SESLKTKMSE LRLYCDLLMQ QVHTIQEFVH HDENHSSPSA ENMNEASSLL SATCNTFITT LEECVKIANA KFKPEMFQLH HPDPLVSPVS PSPVQMMKRS VSHPGSCSSE RSSHSIKEPV STLHRLSQRR RRTYSDTDSC SDIPLEDPDR PVHCSKNTLN GDLASATIPE ESRLMAKKQS ESEDTLPSFS S (1-300 aa encoded by BC044567)
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- M4G3LN
- Vial size
- 25 µg
- Concentration
- 0.5 mg/mL
- Storage
- 4° C
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoblotting of reduced lysates from normal human peripheral blood cells treated with hydrogen peroxide-activated sodium orthovanadate (lane 1) or left untreated (lane 2), and probed with 5 µg/mL of Anti-Human/Mouse Phospho-BTK/ITK (Y551/Y511) Purified.Bands were visualized using Rat Anti-Mouse IgG HRP.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry of formalin-fixed paraffin embedded human tonsil using 0.5 µg/mL of Anti-Human/Mouse Phospho-BTK/ITK (Y551/Y511) Purified, followed by Anti-Mouse IgG Biotin, Streptavidin HRP and DAB visualization.Nuclei are counterstained with hematoxylin.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 8 Enrichment and activation of B cell-associated signaling pathways in HS skin. Analysis of the signal transduction networks using literature-based networks (Genomatix-Pathway System, GePS) demonstrated enrichment for pathways involved in B cell signaling and activation ( A ). To confirm the nature of the inflammatory infiltrate in HS and the localization of components of the enriched signaling pathways, we performed IHC in an excisional biopsy for CD3, CD20, and CD138. Plasma cells were the predominant inflammatory infiltrate and most prominent in the deeper layers of the skin surrounding a deeper sinus tract ( A ), accompanied by increased expression of BTK, SYK, and LCK ( B ) ( n = 3). Activation of key components of this signaling pathway was confirmed by IHC for both phospho-BTK and phospho-SYK ( n = 3) ( C ).