OSGIN1

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

Description

Oxidative stress induced growth inhibitor 1

Tissue specificity

Tissue enriched (liver)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (83931311 - 83966332)

Ensembl ID

ENSG00000140961  (ver. 103.38)

Orthologs

Mouse Osgin1: ENSMUSG00000074063

UniProt

Q9UJX0

neXtProt

NX_Q9UJX0

Human splice variants
Mouse splice variants

Protein structure