PSG6

This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Description

Pregnancy specific beta-1-glycoprotein 6

Tissue specificity

Tissue enriched (placenta)

Predicted location

Intracellular, Secreted in female reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

19 (42902086 - 42919563)

Ensembl ID

ENSG00000170848  (ver. 103.38)

Orthologs

-

UniProt

Q00889

neXtProt

NX_Q00889

Human splice variants

Protein structure