BCAM

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Description

Basal cell adhesion molecule (Lutheran blood group)

Tissue specificity

Tissue enhanced (kidney)

Subcell location

Nucleoli fibrillar center

Predicted location

Intracellular, Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (44809071 - 44821421)

Ensembl ID

ENSG00000187244  (ver. 103.38)

Orthologs

Mouse Bcam: ENSMUSG00000002980

UniProt

P50895

neXtProt

NX_P50895

Human splice variants
Mouse splice variants

Protein structure