APOC1

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

apolipoprotein C1

Protein family

Cancer-related genes, Candidate cardiovascular disease genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

19:q13.32 (44914247 - 44919349)

Ensembl ID

ENSG00000130208  (ver. 99.38)

Orthologs

Mouse Apoc1: ENSMUSG00000040564

UniProt

P02654

neXtProt

NX_P02654

Human splice variants
Mouse splice variants