DPP10

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

Dipeptidyl peptidase like 10

Tissue specificity

Tissue enhanced (adrenal gland, brain, pancreas)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (114442299 - 115845780)

Ensembl ID

ENSG00000175497  (ver. 103.38)

Orthologs

Mouse Dpp10: ENSMUSG00000036815

UniProt

Q8N608

neXtProt

NX_Q8N608

Human splice variants
Mouse splice variants

Protein structure