Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
LITAF
Lipopolysaccharide induced TNF factorFLJ38636, PIG7, SIMPLE, TP53I7
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Top validated antibodies |
|||||
| Proteintech Group |  16797-1-AP |
1 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
| Invitrogen Antibodies | 16797-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
|
||
| Atlas Antibodies | HPA006960 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Novus Biologicals | NBP1-83473 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| GeneTex | GTX109173 |
Polyclonal |
WB
IP
IHC
ChIP
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider