PPM1E

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Description

Protein phosphatase, Mg2+/Mn2+ dependent 1E

Tissue specificity

Group enriched (brain, retina)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (58755854 - 58985179)

Ensembl ID

ENSG00000175175  (ver. 103.38)

Orthologs

Mouse Ppm1e: ENSMUSG00000046442

UniProt

Q8WY54

neXtProt

NX_Q8WY54

Human splice variants
Mouse splice variants

Protein structure