TBPL1

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

Description

TATA-box binding protein like 1

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

6 (133952170 - 133990432)

Ensembl ID

ENSG00000028839  (ver. 103.38)

Orthologs

Mouse Tbpl1: ENSMUSG00000071359

UniProt

P62380

neXtProt

NX_P62380

Human splice variants
Mouse splice variants

Protein structure