ARHGAP29

Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]

Description

Rho GTPase activating protein 29

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

1:p22.1 (94148988 - 94275068)

Ensembl ID

ENSG00000137962  (ver. 99.38)

Orthologs

Mouse Arhgap29: ENSMUSG00000039831

UniProt

Q52LW3

neXtProt

NX_Q52LW3

Human splice variants
Mouse splice variants