WDR12

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit. [provided by RefSeq, Dec 2008]

Description

WD repeat domain 12

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (202874261 - 203014798)

Ensembl ID

ENSG00000138442  (ver. 103.38)

Orthologs

Mouse Wdr12: ENSMUSG00000026019

UniProt

Q9GZL7

neXtProt

NX_Q9GZL7

Human splice variants
Mouse splice variants

Protein structure